Role of biophysics and mechanobiology in podocyte physiology

J Haydak, EU Azeloglu - Nature Reviews Nephrology, 2024 - nature.com
… ) phenotype showed that slit diaphragm density strongly correlates … and integrin-linked kinase,
which is an adaptor protein and a … signalling pathway is activated, are important podocyte

Abnormal crosstalk between endothelial cells and podocytes mediates tyrosine kinase inhibitor (TKI)-induced nephrotoxicity

X Gu, S Zhang, T Zhang - Cells, 2021 - mdpi.com
… of VEGF signaling, NRP1 plays an important role in … β-integrin, playing a key role in regulating
integrin-mediated … structure of the podocytes and the integrity of the slit diaphragm. The …

α-Parvin defines a specific integrin adhesome to maintain the glomerular filtration barrier

M Rogg, JI Maier, C Van Wymersch… - Journal of the …, 2022 - journals.lww.com
… -kinase integrin-linked kinase (ILK) as a component of the … mechano-transductive signaling.
We demonstrate that … The three-dimensional (3D) SIM (z-stack) images of slit diaphragms

[HTML][HTML] Research progress on the pathological mechanisms of podocytes in diabetic nephropathy

L Zhang, Z Wen, L Han, Y Zheng, Y Wei… - Journal of diabetes …, 2020 - hindawi.com
signaling pathways play important roles in the progression of … results in a loss of the slit
diaphragm. The expression of nephrin, … Liu, “Inhibition of integrin-linked kinase blocks podocyte

Integrin β3 overexpression contributes to podocyte injury through inhibiting RhoA/YAP signaling pathway

Z Li, Z Lian, J Ma, L Zhang, X Lian, S Liu, J Xie… - …, 2021 - Taylor & Francis
… the RhoA-YAP axis is the main purpose of the present study. … an important role in the normal
function of glomerular podocytes. … By closing this message, you are consenting to our use of …

[PDF][PDF] Higher Baseline Integrin Beta-1 Level Associated with Possible Increase in the Remission of Steroid-Resistant Nephrotic Syndrome Using Cyclophosphamide …

D RACHMADI, A WIDIASTA… - International Journal …, 2021 - researchgate.net
Integrin-linked kinase (ILK) bridged the integrin and slit diaphragm signaling, as its function
… actinin-4 distribution in maintaining the integrity of slit diaphragm and podocyte architecture. …

[HTML][HTML] Role of transient receptor potential canonical channel 6 (TRPC6) in diabetic kidney disease by regulating podocyte actin cytoskeleton rearrangement

Q Wang, X Tian, Y Wang, Y Wang, J Li… - Journal of diabetes …, 2020 - hindawi.com
… diastolic functions and also serve as a bridge linking intracellular molecular signaling pathways;
… adhesion complexes, including α3β1 integrin, integrin-linked kinase, and talins, have all …

Reconstitution of the kidney glomerular capillary wall

TD Kalejaiye, JA Holmes, R Bhattacharya… - Regenerative …, 2022 - Elsevier
… , dystroglycans confer adhesive cues to the podocytes by bridging actin filaments with …
podocyte adhesome and slit diaphragm signaling via the assembly of integrin-linked kinases with …

CHILKBP protects against podocyte injury by preserving ZO-1 expression

C Guo, Y Ding, A Yang, Y Geng, C Liu, L Zhou… - Cellular and Molecular …, 2023 - Springer
… Our findings reveal a novel signaling pathway consisting of … hair follicle development through
regulating integrin signaling and actin … at podocyte slit diaphragm and functions as a central

Srgap1 controls small rho gtpases to regulate podocyte foot process maintenance

M Rogg, JI Maier, R Dotzauer, N Artelt… - Journal of the …, 2021 - journals.lww.com
… morphology and adhesion via integrin adhesion complexes (… of slit diaphragms and
progressive detachment of podocytes … view of Rho GTPase signaling in podocytes on the level of …